Procaine penicillin is used to treat many different types of
infections caused by bacteria, including syphilis.
A previous hypersensitivity reaction to any penicillin is a
Penicillin is a substance of low toxicity but does possess a
significant index of sensitization. The following hypersensitivity
reactions associated with use of penicillin have been reported:
Skin rashes, ranging from maculopapular eruptions to exfoliative
dermatitis; urticaria; serum-sicknesslike reactions, including
chills, fever, edema, arthralgia, and prostration. Severe and often
fatal anaphylaxis has been reported . As with other treatments for
syphilis, the Jarisch-Herxheimer reaction has been reported.
Procaine toxicity manifestations and hypersensitivity reactions
have been reported.
Pseudomembranous colitis has been reported with the use of
penicillin G. Onset of pseudomembranous colitis symptoms may occur
during or after antibiotic treatment.
Tetracycline, a bacteriostatic antibiotic, may antagonize the
bactericidal effect of penicillin and concurrent use of these drugs
should be avoided.
Concurrent administration of penicillin and probenecid increases
and prolongs serum penicillin levels by decreasing the apparent
volume of distribution and slowing the rate of excretion by
competitively inhibiting renal tubular secretion of penicillin.
Precautions & Warning:
Before using this medication, tell your doctor or pharmacist if you
are allergic to it; or to penicillin or cephalosporin antibiotics;
or to procaine; or if you have any other allergies.Before using
this medication, tell your doctor or pharmacist your medical
history, especially of: kidney disease, asthma.Kidney function
declines as you grow older. This medication is removed by the
kidneys. Therefore, elderly people may be at greater risk for side
effects while using this drug.Kidney function is not fully
developed in newborns/infants. This medication is removed by the
kidneys. Therefore, newborns/infants may be at greater risk for
side effects while using this drug.During pregnancy, this
medication should be used only when clearly needed. Discuss the
risks and benefits with your doctor.This drug passes into breast
milk. Consult your doctor before breast-feeding.
During pregnancy, this medication should be used only when clearly
needed. Discuss the risks and benefits with your doctor.This drug
passes into breast milk. Consult your doctor before breast-feeding.
Treatment / antidote in The Event of Overdose:
See emergency medical attention if you think you have used too much
of this medicine. Overdose symptoms may include mood changes,
agitation, confusion, and seizure
Store below 25 degrees celsius. Protect from moisture. Keep out of
reach of children.