Metronidazole is the drug of choice for symtopmatic intestinal and
extraintestinal amebiasis as well as infections with Trichomonas
vaginalis and Giardia lamblia. It is quickly and reliably effective
against Gardnerella vaginosis.
Hypersensitivity to metronidazole. Safety in pregnancy and
lactation has not been established. Patients with blood dyscrasias
or with active disease of the central nervous system.
The adverse effects of metronidazole are generally dose-related.
The most common are gastro-intestinal disturbances, especially
nausea and an unpleasant metallic taste; nausea is sometimes
accompanied by headache, anorexia and vomiting. Diarrhoea, dry
mouth, a furred tongue, glossitis and stomatitis may also occur.
There have also been rare reports of antibiotic-associated with
Peripheral neuropathy, usually presenting as numbness or tingling
in the extremities, and epileptiform seizures are serious adverse
effects on the nervous system that have been associated especially
with high doses of metronidazole or prolonged treatment.
Psychiatric disturbances such as confusion and hallucinations have
been reported. Weakness, dizziness, ataxia, drowsiness, insomnia,
and changes in mood or mental state such as depression or confusion
have also been reported.
This product can enhance the role of warfarin and other
anticoagulants, can interfere with oxytetracycline combined
metronidazole clear Trichomonas vaginalis.
Precautions & Warning:
Patients should be advised not to take alcohol during metronidazole
therapy and for at least one day afterwards because of the
possibility of a disulfiram-like reaction. Metronidazole enhances
the effect of warfarin.
Use in Pregnancy and Nursing Mothers:
Pregnant and lactating women disabled.
Treatment/antidote in The Event of Overdose:
Large doses can cause convulsions. Treatment is symptomatic and
Store below 25ºC. Protect from moisture. Keep out of reach of children.