Phcnoxymethylpenicillin is indicated in the treatment of mild to
moderately severe infections due to microorganisms whose
susceptibility to penicillin G is within the range of serum levels
common to this particular dosage form. Therapy should be guided by
bacteriologic studies (including susceptibility tests) and by
NOTE: Severe pneumonia, empyema, bacteremia, pericarditis,
meningitis, and arthritis should not be treated with
Phenoxymethylpenicillin during the acute stage.
Phenoxymelhylpenicillin is active mainly to the followings:
Streptococcal Infections (without bacteremia); Pneumococcal
Infections; Staphylococcal Infections Susceptible to Penicillin G;
Fusospirochetosis (Vincent’s Gingivitis and Pharyngitis); Medical
Conditions in Which Oral Penicillin Therapy Is Indicated as
A previous hypersensitivity reaction to any penicillin is a
Dosage and administration:
The usual dosage recommendations for adults and children 12 years
and over are as follows: Streptococcal Infections: Mild to
moderately severe infections of the upper respiratory tract,
including scarlet fever and mild erysipelas; 200,000 to 500,000
units every 6 to 8 hours for 10 days. Pneumococcal Infections: Mild
to moderately severe infections of the respiratory tract, including
otitis media: 400,000 to 500,000 units every 6 hours until the
patient has been afebrile for at least 2 days.
Staphylococcal Infections: Mild infections of skin and soft tissue
(culture and susceptibility tests should be performed): 400,000 to
500,000 units every 6 to 8 hours. Fusospirochetosis (Vincent’s
Infection) of the Oropharynx: Mild to moderately severe infections:
400,000 to 500,000 units every 6 to 8 hours.
Prophylaxis in the Following Conditions: To prevent recurrence
following rheumatic fever and/or chorea: 200,000 to 250,000 units
twice daily on a continuing basis.
Warnings and precautions:
Serious anaphylactic reactions require immediate emergency
treatment with epinephrine. Oxygen, intravenous steroids, and
airway management, including intubation, should also be
administrated as indicated.
Pseudomembranous colitis has been reported with nearly all
antibacterial agents including penicillins, and may range in
severity from mild to life-threatening. Therefore, it is important
to consider this diagnosis in patients who present with diarrhea
subsequent to the administration of antibacterial agents.
Penicillin should be used with caution in individuals with
histories of significant allergies and/or asthma.
The oral route of administration should not be relied upon in
patients with severe illness or with nausea, vomiting, gastric
dilatation, cardiospasm, or intestinal hypermotility. Occasional
patients will not absorb therapeutic amounts of orally administered
In streptococcal infections, therapy must be sufficient to
eliminate the organism (a minimum of 10 days); otherwise, the
sequelae of streptococcal disease may occur. Cultures should be
taken following completion of treatment to determine whether
streptococci have been eradicated.
Prolonged use of antibiotics may promote the overgrowth of
nonsusceptible organisms, including fungi.
If superinfection occurs, appropriate measures should be taken
Store below 25℃. Protect from moisture. Keep out of reach of