It is a solution of modified globulin prepared from immunized
plasma of healthy horses by peptic digestion and ammonium sulphate
fractiontion for preventing of tetanus.
indication and use
1. For those openly wounded, especially those wounded deeply and
contaminated seriously, and in danger of being infected with
tetanus, prophylactic injection of tetanus antitoxin should be
given at once. Patients who have had previous injection of tetanus
toxoid should be boosted with one more injection of tetanus toxoid
(but not tetanus antitoxin). To those who haven't had previous
tetanus toxoid injection or without a clear history of
immunization, both antitoxin and toxoid should be given for
prophylaxis and permanent immunocompetence.
2. The right site for subcutaneous injection of the tetanujs
antitoxin is around the deltoid muscle of the upper arm. If tetanus
toxoid is to be given at the same time, separate sites are
desirable. The right site for intramuscular injection is the centre
area of the deltoid muscle or the lateral upper part of the gluteus
Intravenous route should not be used until no untoward reaction
occurs after intramuscular or subcutaneuos injection. Intravenous
injection should be done slowly enough: Not more than 1ml/min at
the beginning and don't exceed 4ml/min afterward.
The total volume for a single dose should be not more than 40ml for
adults and not more than 0.8ml of body weight for children. Tetanus
antitoxin may be diluted with dextrose solution or physiological
saline for intravenous drip. The drip must be stopped at once if
any untoward reaction occurs.
Validity: 36 monthsths
Storage: In the dark at 2-8 degree, and not be allowed to freeze.