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Anhui Medipharm Co.,Ltd.
ANHUI MEDIPHARM CO.,LTD.
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Metoclopramide Injection 10mg/2ml 10's/box, the drug relief of symptoms associated with acute and so on, GMP

Anhui Medipharm Co.,Ltd.
Anhui Medipharm Co.,Ltd.
City: Hefei
Province/State: Anhui
Country/Region: China
Tel: 86-0551-63840330
Contact Person:
Mrs Jeny

Metoclopramide Injection 10mg/2ml 10's/box, the drug relief of symptoms associated with acute and so on, GMP

Place of Origin : China
Brand Name : Medipharm/OEM
Certification : GMP,ISO
Model Number : AMC14017-02
MOQ : 10000BOXES
Packaging Details : 10mg/2ml, 10pcs/box
Delivery Time : within 45 days
Payment Terms : T/T, L/C, Western Union
Supply Ability : 10000ctns per month
Shelf life : 3 YEARS
Specification : 10mg/2ml 10's/box
Registration dossiers : Available
OEM : Available
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Indications:

Metoclopramide hydrochloride is indicated for the relief of symptoms associated with acute and recurrent diabetic gastric stasis.

Adverse Effects:

In general, the incidence of adverse reactions correlates with the dose and duration of metoclopramide administration. The following reactions have been reported, although in most instances, data do not permit an estimate of frequency

Drug Interactions:

The effects of metoclopramide on gastrointestinal motility are antagonized by anticholinergic drugs and narcotic analgesics. Additive sedative effects can occur when metoclopramide is given with alcohol, sedatives, hypnotics, narcotics, or tranquilizers.

The finding that metoclopramide releases catecholamines in patients with essential hypertension suggests that it should be used cautiously, if at all, in patients receiving monoamine oxidase inhibitors.

Absorption of drugs from the stomach may be diminished (e.g., digoxin) by metoclopramide, whereas the rate and/or extent of absorption of drugs from the small bowel may be increased (e.g., acetaminophen, tetracycline, levodopa, ethanol, cyclosporine).

Gastroparesis (gastric stasis) may be responsible for poor diabetic control in some patients. Exogenously administered insulin may begin to act before food has left the stomach and lead to hypoglycemia. Because the action of metoclopramide will influence the delivery of food to the intestines and thus the rate of absorption, insulin dosage or timing of dosage may require adjustment.

Precautions & Warning

In one study in hypertensive patients, intravenously administered metoclopramide was shown to release catecholamines; hence, caution should be exercised when metoclopramide is used in patients with hypertension.

Intravenous injections of undiluted metoclopramide should be made slowly allowing 1 to 2 minutes for 10 mg since a transient but intense feeling of anxiety and restlessness, followed by drowsiness, may occur with rapid administration.

Because metoclopramide produces a transient increase in plasma aldosterone, certain patients, especially those with cirrhosis or congestive heart failure, may be at risk of developing fluid retention and volume overload. If these side effects occur at any time during metoclopramide therapy, the drug should be discontinued.

Intravenous administration of REGLAN Injection (metoclopramide injection) diluted in a parenteral solution should be made slowly over a period of not less than 15 minutes.

Giving a promotility drug such as metoclopramide theoretically could put increased pressure on suture lines following a gut anastomosis or closure. This possibility should be considered and weighed when deciding whether to use metoclopramide or nasogastric suction in the prevention of postoperative nausea and vomiting

Use in Pregnancy and Nursing Mothers:

Pregnancy Category B

Reproduction studies performed in rats, mice and rabbits by the IM, IV, subcutaneous (SC), and oral routes at maximum levels ranging from 12 to 250 times the human dose have demonstrated no impairment of fertility or significant harm to the fetus due to metoclopramide. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Nursing Mothers

Metoclopramide is excreted in human milk. Caution should be exercised when metoclopramide is administered to a nursing mother.

Contra-indications:

Metoclopramide should not be used whenever stimulation of gastrointestinal motility might be dangerous, e.g., in the presence of gastrointestinal hemorrhage, mechanical obstruction, or perforation.

Metoclopramide is contraindicated in patients with pheochromocytoma because the drug may cause a hypertensive crisis, probably due to release of catecholamines from the tumor. Such hypertensive crises may be controlled by phentolamine.

Metoclopramide is contraindicated in patients with known sensitivity or intolerance to the drug.

Metoclopramide should not be used in epileptics or patients receiving other drugs which are likely to cause extrapyramidal reactions, since the frequency and severity of seizures or extrapyramidal reactions may be increased.

Storage instructions:

Store below 25℃. Protect from moisture. Keep out of reach of children.



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