Ampicillin works by interfering with the ability of bacteria to
form cell walls. The cell walls of bacteria are vital for their
survival. They keep unwanted substances from entering their cells
and stop the contents of their cells from leaking out. Ampicillin
impairs the bonds that hold the bacterial cell wall together. This
allows holes to appear in the cell walls and so kills the bacteria.
A history of a previous hypersensitivity reaction to any of the
penicillins is a contraindication.
Severe allergic reactions (rash; hives; itching; difficulty
breathing; tightness in the chest; swelling of the mouth, face,
lips, or tongue); bloody stools; severe diarrhea; stomach
pain/cramps; vaginal irritation or discharge.
Probably do not affect hormonal birth control such as pills, patch,
or ring, some antibiotics may decrease their effectiveness. This
could cause pregnancy. Examples include rifamycins such as rifampin
or rifabutin. Be sure to ask your doctor or pharmacist if you
should use additional reliable birth control methods while using
this antibiotic. Ampicillin may cause false positive results with
certain diabetic urine testing products (cupric sulfate-type). This
drug may also affect the results of certain lab tests. Make sure
laboratory personnel and your doctors know you use this drug.
Precautions & Warning:
Serious and occasionally fatal hypersensitivity (anaphylactoid)
reactions have been reported in patients on penicillin therapy.
Although anaphylaxis is more frequent following parenteral therapy,
it has occurred in patients on oral penicillins. These reactions
are more apt to occur in individuals with a history of penicillin
hypersensitivity and/or a history of sensitivity to multiple
allergens. The possibility of superinfections with mycotic
organisms or bacterial pathogens should be kept in mind during
therapy. In such cases, discontinue the drug and substitute
Use in Pregnancy and Nursing Mothers:
Ampicillin is excreted in trace amounts in human milk. Therefore,
caution should be exercised when Ampicillin-class antibiotics are
administered to a nursing woman.
Treatment/antidote in The Event of Overdose:
Symptoms: Neurologic symptoms, including convulsions. Treatment:
Both ampicillin and sulbactam may be removed by hemodialysis.
Store below 25℃. Protect from moisture. Keep out of reach of